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Proteomics/Mass Spectrometry

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The Proteomics Core Facility combines in-depth expertise with state-of-the-art facilities for the large-scale characterization of proteins expressed in health and disease. Proteins are the players of essentially all cellular processes and constitute the vast majority of therapeutic drug targets. Thus, the systematic analysis of proteins and in particular their patterns of expression, interactions and modifications is now a valuable approach for defining key cellular processes at molecular level. Our scientific team has experience in all facets of proteomics analysis including sample processing for high-resolution 2D gel electrophoresis, multidimensional chromatography, isotopic labeling mass spectrometry analysis by ESI/MS/MS, sequence analysis, and bioinformatics. These results, in conjunction with genomic database comparisons, enable us to describe the potential role of novel proteins identified through our proteomics discovery platform. In addition to in-house research, The Facility is accessible to any academic investigators from any institution as well as industrial clients.

We offer:

  • Liquid chromatography
  • Protein and peptide purification
  • 1D and 2D gel electrophoresis
  • Gel imaging and analysis
  • Sample processing (isotope labeling, enzymatic digestion and fractionation)
  • MALDI-TOF peptide mass fingerprint (PMF)
  • Protein identification (Protein ID)
  • Phosphopeptide mapping (TiO2IMAC, LC-MS/MS approaches)
  • Protein profiling though MudPIT, ITRAQ or SILAC
  • Biomarker discovery
  • Metabolite ID and quantitation
  • De novo peptide sequencing
  • Amino acid analysis

We work closely with our clients in a professional and confidential manner. Our client list includes academic and commercial institutions from around the world.

For more information, we invite you to contact Dr Qishan Lin at 518-591-7214 or at linq@albany.edu.

 

Instrumentation | Fees Schedule | Sample Submission | Sample Preparation | Protocols | FAQ | Useful Links | Applications


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