CFG Staff

Qishan Lin, Ph.D.

Director, UAlbany Proteomics Facility
Research Associate Professor
Department of Biomedical Sciences
School of Public Health

Academic Background

• Ph.D. (Analytical Chemistry) 1996, Chinese Academy of Sciences, China
• MSc. (Organic Chemistry) 1991, Chinese Academy of Sciences, China
• B.S. (Chemistry) 1988, National University of Defense and Technology, China

Professional Background

• Chief Proteomics Scientist, Myomatrix Therapeutics, Rensselaer, NY (2001-2002)
• Postdoctoral Fellow, Albany Medical College, Albany, NY (2001-2002)
• Research associate, Howard Hughes Medical Institute, Seattle, WA (1997-2000)
• Postdoctoral Fellow, Department of Biochemistry, University of Washington, Seattle, WA (1997-2000)
• Research Associate Professor, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China (1997)
• Practice Research Assistant Professor, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China (1991-1996)

Research Experience

• Comparative study of phycobiliprotein from four types of marine blue and red alga (Bangia fusco-purpurea, Porphyra haianensis, P.yezoensis and Spirulina platensis) with respect to their separation techniques, structure and functions
• Study on synthesis of new type of chromatographic media and its application in bonded phase of reversed, hydrophobic, ion exchange, size exclusion and affinity chromatography
• Purification and characterization of transthyretin from human blood, and Development of new labeling reagent for sub-fmol level mono-saccharide analysis for glyco-protein by HPLC and HPCE
• Enzymatic study of a phosphatidic acid-preferring phospholipase A1 (PA-PLA1) from bovine testis using vesicle assay system; Identification and sequencing species- or tissue-specific iso-forms of PA-PLA1 in bovine sperm cells by means of high-resolution two dimensional gel electrophoresis and Nano-HPLC/electrospray mass spectrometry
• Using liposome artificial membrane to probe the kinetics of the interfacial enzymes
• Structural and functional study of a novel angiotensinase from a failing human heart; Proteomic approach to profile membrane proteins in a failing human heart vs. non-failing human heart; Proteomic charaterization neonatal rat cardiomyocytes; Application of proteomics approach to identify trans-regulatory networks of myosin heavy chain
• Application proteomics approaches including high-resolution 2D electrophoresis, multidimensional chromatography, mass spectrometry, and database to infer and describe biological process

Research Interests

• Quantitative proteomics foromarker discovery and validation
• Chemical proteomics
• Development of novel platforms for post-translational modification identification including phosphorylation, methylation and acetylation
• Development of nanospray LC-multiple reaction monitoring (MRM)-MS assays for biological applications
• Kinetically stable proteins: applications to conformational diseases

Selected Publications

http://www.ncbi.nlm.nih.gov/pubmed?term=Lin%20Qishan

• Lu, Heng; Wang, Xianhui; Li, Tianshu; Urvalek, Alison M.; Yu, Lin; Li, Jieli; Zhu, Jinghua; Lin, Q.; Peng, Xu; Zhao, Jihe
  Identification of poly(ADP-ribose) polymerase-1 (PARP-1) as a novel Krueppel-like factor 8-interacting and -regulating protein (2011)
  Journal of Biological Chemistry, 286(23), 20335-20344
• Dyavaiah, M., Rooney, J., Chittur, S., Lin, Q., and Begley, T., (2011)
  Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase
  Molecular Cancer Research, 9(4):462.
• Urvalek, A.M., Heng, L., Wang, X., Li, T., Yu, L., Zhu, J., Lin, Q., Zhao, J.
  Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation (2011)
  American Journal of Translational Research, 3(2):121-132
• Xu, H.Z, Huang, Y., Wu, Y., Zhao, Y., Xiao, W., Lin, Q., Sun, H., Dai, W., and Chen, G.
  Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function (2010)
  Cell Cycle, 9(14): 1-11
• Gong, Y., C. F. Lippa, Zhu, J., and Lin, Q.
  Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease (2009)
  Brain Res, 1292: 191-8.
• Zhe, W., Ning, T., Sun, Y., Zhu, J., Zhu, Y., Lin, Q., He, G.
  Understanding rice plant resistance to the Brown Planthopper (Nilaparvata lugens): a proteomic approach (2009)
  PROTEOMICS, 9(10), 2798-2808.
• Luo, J., Ning, T., Sun, Y., Zhu, J., Zhu, Y., Lin, Q., Yang, D.
  Proteomic Analysis of Rice Endosperm Cells in Response to Expression of hGM-CSF(2009)
  J Proteome Res, 8(2), 829-837.
• Manning, M., Hesham, H., Lin, Q., Colon, W
  The subproteome of kinetically stable proteins in Escherichia Coli (2007)
  PNAS, 104(44), 17329-34.
• Zheng, X, Teck Ho Lee, R, Wang, Y, Lin, Q. and Wang, Yue
  Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth (2007)
  The EMBO Journal, 26, 3760-3769
• Snelling, W., Lin, Q., Moore, J., et al.
  A proteomic analysis of Cryptosporidium parvum and of protein expression during excystation (2007)
  Molecular and Cellular Proteomics, 6, 346-355

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