CFG Staff

Ana V. Perez

Director, Mouse Transgenic Facility

Academic Background

• Ph.D. (Molecular and Developmental Biology) 1992, Columbia University, New York.
• M.Phil. (Molecular and Developmental Biology) 1990, Columbia University, New York.
• M.A. 1988, Columbia University, New York.
• Licentiate in Biology. 1985, Cayetano Heredia University, Lima, Peru.
• Licentiate in Chemistry. 1985, Cayetano Heredia University, Lima, Peru.
• B.Sc. 1984, Cayetano Heredia University, Lima, Peru.

Professional Background

• Research Assistant Professor, Biology Department, University of New Mexico, Albuquerque, NM (2000)
• Post-doctoral Fellow, Biology Department, University of New Mexico, Albuquerque, NM (1996-1999)
• Post-doctoral Fellow, Los Alamos National Laboratory, Los Alamos, NM (1992-1995)
• Research Assistant, Columbia University, New York, NY (1988-1992)

Honors and Awards

• Young Scientist Award, 1992. Federation of American Societies for Experimental Biology (FASEB), Vermont.
• Fieger Predoctoral Scholarship Award, 1991-1992. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.
• Graduate Fellowship Award, 1985-1986. National Council of Science and Technology, Lima, Peru.

Research Experience

• Mouse tendon development. Characterization of gene expression and regulatory elements responsible for tissue tendon expression.
• Characterization and sequencing of genes involved in mouse tendon development.
• Characterization of collagen types I and II, and proteoglycans present in bovine tendon during fibrocartilage development at the mRNA level.
• Characterization of the mouse and human Fibroblast growth factor receptor 3 (Fgfr3) gene and generation of transgenic mice carrying a dominant mutation of Fgfr3.
• Generation of a null mutant mouse of the centromeric CENP-B protein.
• Responsible for the set-up of a mouse transgenic facility at LANL
• Study of the function of the CRABP and CRBP genes during mouse development.
• Characterization of Dsp- mutants in Myxococcus xanthus.
• Effect of organic compounds in the leaching process of Thiobacillus Ferrooxidaans.
• Studies of the nitrogen fraction of Carmine.

Selected Publications

• A.V. Perez , M. Perrine, N. Brainard and K. G. Vogel. " Scleraxis directs lacZ expression in tendon of transgenic mice". Mech Dev 120, 1153 (2003).
• L. Yu, J. Mikloucich, N. Sangster, A. V. Perez and P. J. McCormick. “MyoR is expressed in nonmyogenic cells and can inhibit their differentiation”. Exp Cell Res 289, 162 (2003).
• A.V. Perez-Castro and K. G. Vogel. In situ Expression of Collagen and Proteoglycan Genes during Development of Fibrocartilage in Bovine Deep Flexor Tendon. J. Orthop. Res. 17, 139 (1999).
• A.V. Perez-Castro, F. L. Shamanski, J. J. Meneses, T. L. Lovato, K. G. Vogel, R. K. Moyzis and R. Pedersen. Centromeric Protein B Null Mice are Viable with No Apparent Abnormalities. Dev. Biol. 201, 135 (1998).
• R.T. Okinaka, A. V. Perez-Castro, A. Sena, R. J. Reynolds, M. S. Park, G. Strniste, M. A. MacInnes, and K. A. Kraemer. Heritable Genetic Alterations in Xeroderma Pigmentosum Group G/Cockayne's Syndrome Pedigree. Mutat. Res. 385, 107 (1997).
• A.V. Perez-Castro, J. Wilson, and M. R. Altherr. Genomic Organization of the Human Fibroblast Growth Factor Receptor 3 (FGFR3) Gene and Comparative Sequence Analysis with the Mouse (Fgfr3) gene. Genomics 41, 10 (1997).
• M. R. Altherr, K. Denison, T. Wright, A. V. Perez-Castro, and V. Johnson. Delimiting the Wolf-Hirschhorn Syndrome Critical Region to 750 Kilobase Pairs. Am. J. Med. Genet. 71, 47 (1997).
• D. L. Ludwig, J. S. Mudgett, M. S. Park, A. V. Perez-Castro, and M. A. MacInnes. Molecular Cloning and Structural Analysis of the Functional Mouse Genomic XPG Gene. Mamm. Genome 7, 644 (1996)
• A.V. Perez-Castro, J. Wilson, and M. R. Altherr. Genomic Organization of the Mouse Fibroblast Growth Factor Receptor 3 (Fgfr3) Gene. Genomics 30, 157 (1995)
• A.V. Perez-Castro, V. Tran, and M. C. Nguyen-Huu. Defective Lens Fiber Differentiation and Pancreatic Tumorigenesis caused by Ectopic Expression of the Cellular Retinoic Acid-Binding Protein I. Development 119, 363 (1993).
• A.V. Perez-Castro, L. E. Toth-Rogler, L. Wei, and M. C. Nguyen-Huu. Spatial and Temporal Pattern of Expression of The Cellular Retinoic Acid-Binding Protein and the Cellular Retinol-Binding Protein during Mouse Embyogenesis. Proc. Natl. Acad. Sci. USA 86, 8813 (1989).

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