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CFG Staff

Karen E. Preston

Research Support Specialist

Academic Background

  • M. S. (Zoology) 1983,Virginia Polytechnic Institute and State University, Blacksburg, Virginia
  • B.A. (Biology) 1980, Randolph-Macon Woman's College, Lynchburg, Virginia

Professional Background

  • Research Technologist, Molecular Microbiology, Albany Medical Center Hospital, Albany, NY (1992-2004)
  • Laboratory Technician, Laboratory of Biochemical and Genetic Toxicology, New York State Dept. of Health, Albany, NY (1987-1992)

Awards and Honors

  • Phi Sigma Society, 1981, Virginia Polytechnic Institute and State University, Blacksburg, Virginia
  • Phi Beta Kappa, 1979, Randolph-Macon Woman's College, Lynchburg, Virginia
  • Distinguished Scholar Award, 1976-1980, Randolph-Macon Woman's College, Lynchburg, Virginia

Research Experience

  • Bacterial strain typing by conventional and pulsed-field gel electrophoresis for epidemiological studies
  • Isolation and characterization of plasmids, plasmid- associated antibiotic resistance genes, Β-lactamases, and mobile DNA elements in hospital-acquired Enterobacteriacae
  • Development of gene probes for Southern and dot blots for surveillance of plasmid-encoded resistance and other factors occurring in hospital-acquired bacteria
  • Culture of and detection of antibodies to Helicobacter pylori, a microaerophilic bacterium associated with gastric ulcers
  • Production and screening of mammalian cDNA libraries for the catalase gene, and other genes encoding antioxidant enzymes
  • Polymerase chain reactions, standard and real-time

Selected Publications

  • Preston, K. E., Venezia, R. A., and Stellrecht, K. A.
    The SHV-5 extended-spectrum Β-lactamase gene of pACM1 is located on the remnant of a compound transposon.
    Plasmid 51: 48-53. (2004).

  • Preston, K. E., Graffunder, E. M., Evans, A. M., and Venezia, R. A.
    Survey of plasmid-associated genetic markers in Enterobacteriaceae with reduced susceptibilities to cephalosporins.
    Antimicrob. Agents Chemother. 47: 2179-2185, (2003).

  • Preston, K. E. and Venezia, R. A.
    Chromosomal sequences from Klebsiella pneumoniae flank the SHV-5 extended-spectrum Β-lactamase gene in pACM1.
    Plasmid 48: 73-76, (2002)

  • Preston, K. E., Radomski, C. C. A., and Venezia, R. A.
    Nucleotide sequence of the chromosomal ampC gene of Enterobacter aerogenes.
    Antimicrob. Agents Chemother. 44:3158-3162, (2000)

  • Preston, K. E. and Venezia, R. A.
    Restriction map and properties of Klebsiella oxytoca plasmid pACM1.
    Plasmid 42: 92-103, (1999)

  • Preston, K. E., Radomski, C. C. A., and Venezia, R. A.
    The cassettes and 3´ conserved segment of an integron from Klebsiella oxytoca plasmid pACM1.
    Plasmid 42: 104-114, (1999)

  • Venezia, R. A., Scarano, F. J., Preston, K. E., Steele, L. M., Root, T. P., Limberger, R., and Archinal, W.
    Molecular epidemiology of an SHV-5 extended-spectrum Β-lactamase in Enterobacteriaceae isolated from infants in a neonatal intensive care unit.
    Clin. Infect. Dis. 21: 915-923, (1995)

  • Shaffer, J. B., Preston, K. E., Shepard, B. A.
    Nucleotide and deduced amino acid sequences of mouse catalase: molecular analysis of a low activity mutant.
    Nucleic Acids Res. 18: 4941, (1990)

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